Sermorelin
peptideformerly Geref
Growth-hormone-releasing hormone analog
Research status · Formerly approved / compounded
Previously FDA-approved (Geref, for diagnosing GH deficiency) but the branded product was discontinued for commercial reasons. No FDA-approved sermorelin product is currently marketed; it is available via compounding pharmacies.
Sermorelin is a GHRH analog historically used to assess growth-hormone deficiency and now common in wellness/longevity clinics via compounding. It is usually framed as a gentler secretagogue; it is still clinician-territory.
How it works
GHRH analog stimulating pituitary release of the body's own growth hormone.
Commonly discussed use cases
- Sleep (discussed)
- Recovery (discussed)
- Age-related GH decline (discussed)
Supposed / potential benefits
- Reported subjective sleep/recovery benefits — limited controlled evidence in wellness use
Common side effects
- Injection-site irritation
- Flushing
- Headache
- Dizziness
Warnings & contraindications
- No FDA-approved product currently on the US market
- GH-axis effects warrant labs and clinician oversight
- Compounded product quality varies
Typical timing considerations
Community/clinic discussions mention pre-sleep dosing; only a clinician should direct this.
Administration route
Subcutaneous injection
Storage
Refrigerate after reconstitution; follow pharmacy instructions.
Questions to ask your clinician
- What outcome are we targeting and how will we measure it?
- What labs before/during?
- When would we stop?
Commonly tracked in Reta
Tracking fields organize user-entered, clinician-directed routines — Reta never recommends or computes doses.
Track this in Reta
Beta members get a ready-made tracker for Sermorelin — schedule, dose log, injection-site rotation, reminders, and check-ins — for organizing a clinician-directed routine. Personal tracking is available to everyone during the Public Beta.
Reta is a tracking and education tool — not a medical provider. Nothing here is a diagnosis, treatment, prescription, or dosing recommendation. Peptides and medications should only be used under the direction of a licensed clinician. Talk to a qualified clinician before starting, stopping, combining, or changing anything. Many compounds below are not FDA-approved for human use; some are investigational or sold through unregulated channels where purity and dosing are not guaranteed.