MOTS-c
peptideMitochondrial-derived peptide (investigational)
Research status · Not FDA-approved
Not FDA-approved for human use. Investigational; largely preclinical/early research. Available (where legal) via compounding — verify current status.
MOTS-c is a mitochondrial-derived peptide studied in metabolism and exercise-physiology research. Human clinical evidence is early; it is not an approved medication.
How it works
Proposed to influence metabolic regulation and insulin sensitivity via AMPK-related pathways (largely preclinical).
Commonly discussed use cases
- Metabolic health (research)
- Exercise capacity (research)
Supposed / potential benefits
- Metabolic effects seen mostly in animal/cell studies — not established in humans
Common side effects
- Injection-site reactions
- Limited human safety data
Warnings & contraindications
- Not FDA-approved; human safety/efficacy not established
- Unregulated sourcing risk
Typical timing considerations
No established human regimen; any use should be clinician-directed.
Administration route
Subcutaneous injection
Storage
Refrigerate after reconstitution; follow instructions.
Questions to ask your clinician
- What human evidence exists for my goal?
- How would we monitor safety?
Commonly tracked in Reta
Tracking fields organize user-entered, clinician-directed routines — Reta never recommends or computes doses.
Sources
Track this in Reta
Beta members get a ready-made tracker for MOTS-c — schedule, dose log, injection-site rotation, reminders, and check-ins — for organizing a clinician-directed routine. Personal tracking is available to everyone during the Public Beta.
Reta is a tracking and education tool — not a medical provider. Nothing here is a diagnosis, treatment, prescription, or dosing recommendation. Peptides and medications should only be used under the direction of a licensed clinician. Talk to a qualified clinician before starting, stopping, combining, or changing anything. Many compounds below are not FDA-approved for human use; some are investigational or sold through unregulated channels where purity and dosing are not guaranteed.